Author: CannabisNewsWire (CNW)

About CannabisNewsWire CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge. To receive SMS text alerts from CannabisNewsWire, text “CANNABIS” to 21000 (U.S. Mobile Phones Only) For more information please visit https://www.CannabisNewsWire.com Please see full terms of use and disclaimers on the CannabisNewsWire website applicable to all content provided by CNW, wherever published or re-published: http://CNW.fm/Disclaimer

420 with CNW — A BHO and CO2 Cannabis Extraction Comparison

Despite being prohibited, cannabis has been immensely popular over the past couple of decades. Cannabis proved to be a lucrative space once territories began legalizing the substance for medical and recreational use, but things blew up once cannabis concentrates hit the market. Thanks to constantly improving technology, processors are now able to pull cannabinoids from the plant, creating high-potency cannabis products that have enjoyed major sales.

Extracting cannabinoids and terpenes from hemp and cannabis is an insanely complex process, with the most common extraction methods thus far being butane hash oil (“BHO”) and carbon dioxide (“CO2”) extraction.

BHO, which is a solvent-based extraction method, uses a light hydrocarbon solvent called butane to strip cannabis plants of their resin. Although this method dates back to the 1970s, it can be dangerous because butane is highly flammable, thus requiring specialized training as well as closed-loop equipment for extraction. Closed loop refers to a system that pulls compounds from the cannabis in a completely airtight environment.

If done correctly and under the proper conditions, BHO can produce extracts with up to 90% THC, resulting in high-potency products that can be used for edibles, vaping and topical treatments, among others. Carbon dioxide extraction, on the other hand, uses pressurized CO2 to pull compounds from cannabis. Most of the cannabis oil used in vape cartridges is extracted via CO2 extraction. Like BHO extraction, carbon dioxide extraction requires the use of specialized equipment, and amateurs with no training are advised to avoid both of these extraction methods.

Due to the complexity and newness of BHO and CO2 extraction in the cannabis industry, a lot of people don’t know much about them. For instance, there seems to be a misconception about butane hash leaving residual solvents and producing impure extracts with an unpleasant taste, which is false. In fact, carbon dioxide extraction often uses a second solvent to winterize or crystallize the extract, which has to be removed later on. As a result, extracts made via this process also run the risk of contamination. Additionally, carbon dioxide extraction can be especially dangerous as CO2 extraction systems operate under extremely high pressures, ranging from 1,500-8,700 PSI.

As long as both methods are implemented by trained individuals using the right equipment and in controlled environments, the resultant extract will be quite safe to consume. However, note that there will be slight product differences. Since CO2 extraction calls for a lot of post processing, it may have a reduced natural flavor and a different consistency. It will also take longer compared to BHO processing, which has less post-processing steps. Due to the complexity and equipment required for these extraction methods, consumers should leave extraction to the experts and stick to easier alternatives such as cannabutter and cannaoil.

Consumers are encouraged to stick to high-quality cannabis extracts made by some of the leading companies in the industry, such as Chalice Brands Ltd. (CSE: CHAL) (OTCQB: CHALF), to avoid putting themselves and others at risk while trying to DYI their own extracts.

NOTE TO INVESTORS: The latest news and updates relating to Chalice Brands Ltd. (CSE: CHAL) (OTCQB: CHALF) are available in the company’s newsroom at https://cnw.fm/CHALF

About CNW420

CNW420 spotlights the latest developments in the rapidly evolving cannabis industry through the release of two informative articles each business day. Our concise, informative content serves as a gateway for investors interested in the legalized cannabis sector and provides updates on how regulatory developments may impact financial markets. Articles are released each business day at 4:20 a.m. and 4:20 p.m. Eastern – our tribute to the time synonymous with cannabis culture. If marijuana and the burgeoning industry surrounding it are on your radar, CNW420 is for you! Check back daily to stay up-to-date on the latest milestones in the fast -changing world of cannabis.

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420 with CNW — Clinical Studies Shed Light on Various Wellness Benefits of Phytocannabinoids

The CBD sector is among the fastest-growing subcategories of consumer natural health products and for good reason. A recent report estimates that last year, the international consumer health CBD market was worth more than $9 billion, with an expected compound annual growth rate of nearly 25% in the period between 2020–2027.

Studies linking health and wellness to CBD have also driven the manufacture of products derived from CBD in industries such as food and beverages, nutraceuticals, personal care and cosmetics and pharmaceuticals, for health and wellness purposes.

Verdant Oasis VP Carl Germano states that new research which sheds light on the role of hemp phytocannabinoids such as CBD in supporting the endocannabinoid system will influence medicine and nutrition significantly.

Phytocannabinoids are cannabinoids that occur naturally in the marijuana plant. Thus far, researchers have identified more than 120 terpenes and 100 cannabinoids.

Below are some of the uses of CBD and other phytocannabinoids in wellness applications.

Skin conditions

Research has found that CB1 and CB2, which are cannabinoid receptors, are found in hair follicles, eccrine sweat glands, melanocytes, dermal cells, cutaneous nerve fibers and epidermal keratinocytes. A study that administered CBD to cultured human sebocytes found that CBD could be used as a therapeutic agent for treating acne vulgaris because of its combined anti-inflammatory, anti-proliferative and lipostatic effects.

Dr. Jacknin’s Skincare CEO Jeanette Jacknin asserted that research had shown that topical CBD as well as other cannabinoids could help in wounds, eczema and acne and suggested that cannabinoids may also help with itching.

Anxiety

A recent review that centered on anxiety disorders and CBD found that CBD held significant potential as a treatment for multiple anxiety disorders. CBD also demonstrated effectiveness in decreasing anxiety in social anxiety disorder.

Immune/respiratory health

In a modeling study that simulated symptoms of acute respiratory distress syndrome, treatment using CBD reversed symptoms by increasing the quantity of a peptide known as apelin, which plays a crucial role in the peripheral and central regulation of immunity.

Another study found that cannabidiol could alleviate the uncontrolled cytokine production responsible for damaging lung tissue, in addition to launching numerous anti-inflammatory and immunomodulatory effects.

Bone health

There is increasing evidence that suggests that phytocannabinoids have a positive effect on the musculoskeletal system. Research has found that CB1 and CB2 receptors, which can be found in bones, help to regulate bone maintenance. In animal studies, researchers have discovered that CBD can protect against bone loss and improve the healing of bone tissue.

With more interest and funds being directed to cannabinoid research to discover the therapeutic benefits they deliver, the CBD market is expected to grow significantly in the future.

As more becomes known about the benefits of phytocannabinoids, companies that make cannabinoid supplements and supplements, such as BevCanna Enterprises Inc. (CSE: BEV) (OTCQB: BVNNF) (FSE: 7BC), are likely to benefit.

NOTE TO INVESTORS: The latest news and updates relating to BevCanna Enterprises Inc. (CSE: BEV) (OTCQB: BVNNF) (FSE: 7BC) are available in the company’s newsroom at http://cnw.fm/BVNNF

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CannabisNewsBreaks – Red White & Bloom Brands Inc. (CSE: RWB) (OTCQX: RWBYF) Releases Q4, FY 2020 Financial Reports

Red White & Bloom (CSE: RWB) (OTCQX: RWBYF), a multistate cannabis operator and house of premium brands, has reported fourth quarter and full year 2020 financial results and company highlights. The report noted that Q4 2020 adjusted sales totaled C$28.6 million, an increase of 290% over the third quarter, with fourth quarter 2020 revenue reaching C$15.7 million, an increase of 158% over the third quarter. Finally, full year 2020 adjusted sales topped more than $37.8 million with revenue coming in at $23.3 million. In addition, the announcement noted that RWB closed two significant acquisitions, completed its go-public transaction and established its first THC operations and brands, as well as raised more than $100 million to support expansion and operation efforts. In addition, Red White & Bloom announced that it has scheduled a conference call and audio webcast to provide an overview of the company’s 2020 and Q1 2021 operating results and 2021 outlook; the webcast will also include a Q&A session. Anyone interested can participate by calling (877) 705-6006 toll-free or (201) 689-8557 for international. “We set out at the beginning of 2020 with a three-year plan for our success,” said Red White & Bloom CEO and chair Brad Rogers in the press release. “Our strategy was to establish a foundation for the overall company and identify the core states to operate in and a plan to scale in those states. We have set the foundation for our core states including Michigan, Illinois, Florida and California. In 2021 we look to expand through an asset light approach in other states, such as Arizona, and complete the integration of our M&A targets while gaining operational synergies from all we have accomplished over the last 18 months. For the balance of 2021 and throughout 2022, the company will focus on the continued growth of our topline revenue and bottom-line results through expansion of our house of brands that continue to gain momentum, fortification of our vertically integrated businesses, and the synergies from our M&A success.”

To view the webcast, visit https://cnw.fm/UUj31

To view the full press release, visit https://cnw.fm/G70HR

About Red White & Bloom Brands Inc.

Red White & Bloom Brands is positioning itself to be one of the top-three, multistate cannabis operators active in the U.S. legal cannabis and hemp sector. RWB is predominantly focusing its investments on major U.S. markets, including Michigan, Illinois, Massachusetts, Arizona and California, with respect to cannabis, as well as the United States and internationally for hemp-based CBD products. For more information about the company, please visit www.RedWhiteBloom.com.

NOTE TO INVESTORS: The latest news and updates relating to RWBYF are available in the company’s newsroom at https://cnw.fm/RWBYF

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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420 with CNW — Marijuana Could Have Origins in China, Study Says

After being outlawed in most regions across the world for decades, cannabis is coming out from under the yoke of prohibition. It has been a slow process and although the sector has shown that it has plenty of potential, cannabis still has a long way to go. However, researchers are finally getting the chance to run more in-depth studies on cannabis, and they are uncovering plenty of interesting information.

For starters, a recent study has found evidence pointing to China, specifically the northwest region of China, as home to the first domesticated cannabis and hemp. The common assumption is that cannabis sativa originated from East Asia, but its illegality over the past century has prevented research into its history and use. The study team, helmed by Swiss and Chinese researchers, took advantage of loosening cannabis restrictions and conducted an in-depth study on the history of cannabis and hemp.

The researchers concluded that the cannabis sativa species likely emerged from China’s northwest region by an estimated 10,000 to 3,000 BC (Neolithic period). According to a news release by the journal that published the study, “Science Advances,” cannabis and hemp were among the very first plants to be domesticated by humans, with humans using hemp to produce textiles, food and oilseed.

To arrive at these conclusions, the team compiled 110 whole genomes covering everything from different feral, wild-growing plants and domesticated varieties to modern hemp hybrids and psychoactive cannabis. They separated their genomic analysis samples into four different groups, including basal cannabis which is usually found in the United States and China. The data suggested that basal cannabis diverged from the ancestors of modern marijuana and hemp nearly 12,000 years ago, giving weight to the theory that by that point in history, the cannabis sativa species had been domesticated already. Furthermore, the study says, it coincides with ancient artifacts such as pottery from Southern China, Japan and Taiwan that has been dated to that period.

Once humans in the Neolithic period had domesticated cannabis, it spread across the Middle East and Europe during the Bronze Age, appearing in India nearly 3,000 years ago after likely being introduced with other crops from China, the study says. Cannabis arrived in Africa during the 13th century and traveled to Latin America in the 16th century before reaching North America at the start of the 20th century.

The closest descendants to the ancient hemp and marijuana are modern Chinese cannabis, altered by years of cultivation, and feral, wild-growing cannabis plants, the study says. However, it is likely that the cannabis sativa’s pure wild ancestors have gone extinct.

It is amazing how much researchers continue to learn about marijuana. Sector players such as Hero Technologies Inc. (OTC: HENC) must be having their own fair share of surprising discoveries about this versatile yet controversial plant.

NOTE TO INVESTORS: The latest news and updates relating to Hero Technologies Inc. (OTC: HENC) are available in the company’s newsroom at https://cnw.fm/HENC

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420 with CNW — Senator Files Bill to Protect Licensed Marijuana Extractors from Eviction

Although the past decade has seen America’s state legal cannabis industry experience major growth, federal law has consistently held the sector back. Cannabis is classified as a Schedule I controlled substance, and this classification has been a constant barrier for both businesses in the cannabis space and the clients they serve. Fortunately, an increasing number of lawmakers have noticed the plight of the cannabis sector, which has provided states with millions of dollars in tax revenue, and they have been working to give the space more protections.

After an affordable housing bill failed to advance in Congress last month, Senator Jeff Merkley again introduced a bill that includes a provision preventing landlords from evicting state-licensed people who manufacture cannabis extracts. The bill, whose language is identical to the bill filed last month, has a “just causes for eviction” section containing common reasons for eviction, including defaulting on rent and causing significant property damage. It also lists “manufacture of a cannabis extract” as a legal reason for eviction, adding that tenants who hold a manufacturing license under federal, state or tribal law are exempt.

However, the bill does not provide any protections for tenants who take part in other state-legal cannabis-related activities such as possession. Curiously, the bill contains language that states that manufacturing, delivering or possessing controlled substances is enough grounds for eviction. Since cannabis is technically a controlled substance according to federal law, some landlords could choose to defer to federal law rather than state law and evict tenants who perform any of the aforementioned actions.

The inclusion of language offering protections for individuals who take part in state-legal cannabis activities in an affordable housing bill will definitely make cannabis reform advocates happy, but it may very well be inconsequential. This is because eviction proceedings tend to be handled at the state level; the assumption is that courts would turn to state law when dealing with eviction cases that concern cannabis.

Additionally, the chances of an individual being licensed by the state to perform cannabis manufacturing activities at their premises are close to zero. As such, it is not clear just how impactful the provision for manufacturing licenses would be if the proposed policy becomes law.

The comprehensive housing bill, which contains the cannabis provision, aims to correct the pitfalls of America’s housing policies and funding by addressing systemic disparities and obstacles and ensuring every American, especially the most vulnerable, has an equitable outcome.

The entire cannabis industry, including companies such as Red White & Bloom Brands Inc. (CSE: RWB) (OTCQX: RWBYF), may regard the rolling back of restrictions on housing as a bonus in the drive to see the cannabis industry federally legalized and given equal treatment as other legal sectors.

NOTE TO INVESTORS: The latest news and updates relating to Red White & Bloom Brands Inc. (CSE: RWB) (OTCQX: RWBYF) are available in the company’s newsroom at https://cnw.fm/RWBYF

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CannabisNewsBreaks – The Alkaline Water Company Inc. (NASDAQ: WTER) (CSE: WTER) Announces Accelerated Growth for Alkaline88(R)

The Alkaline Water Company (NASDAQ: WTER) (CSE: WTER), the country’s largest independent alkaline water company, today announced that its bulk three-liter and best-selling one-gallon bottles will be added to five warehouses of Associated Wholesale Grocers (“AWG”), the nation’s largest cooperative food wholesaler to independently owned supermarkets. According to the update, AWG serves over 1,100 member companies and over 3,000 locations throughout 28 states. Alkaline88(R) will be added to AWG’s warehouses in Louisiana, Kansas, Missouri, Oklahoma, and Wisconsin. “The addition of Associated Wholesale Grocers’ (‘AWG’) five strategically located warehouses comes at the perfect time for our company. Our supply chain has never been stronger, and our sales continue to accelerate in all channels,” said Ricky Wright, president and CEO of The Alkaline Water Company. “The 12-week SPINS ending June 13, 2021, for total U.S. Mulo, Food and Natural Channels, shows Alkaline88 sales have grown 33.7% year over year. More exciting is that in the last four weeks we have accelerated to 39.6% year-over-year growth. Much credit is due to our outstanding sales team and their outstanding efforts. With Associated Wholesale Grocers, Alkaline88 has another opportunity to even further accelerate our growth for the remainder of fiscal 2022.”

To view the full press release, visit https://cnw.fm/vlMeI

About The Alkaline Water Company

Founded in 2012, The Alkaline Water Company is headquartered in Scottsdale, Arizona. Its flagship product, Alkaline88(R), is a leading premier alkaline water brand available in bulk and single-serve sizes along with eco-friendly aluminum packaging options. With its innovative, state-of-the-art proprietary electrolysis process, Alkaline88 delivers perfect 8.8 pH-balanced alkaline drinking water with trace minerals and electrolytes and boasts its trademarked label: Clean Beverage. Quickly being recognized as a growing lifestyle brand, Alkaline88 launched A88 Infused(TM) in 2019 to meet consumer demand for flavor-infused products. A88 Infused flavored water is available in six unique, all-natural flavors with new flavors coming soon. Additionally, in 2020, the company launched A88 Infused Beverage Division Inc., which includes the company’s CBD water and flavor-infused water. For the company’s topical and ingestible offerings, A88 Infused Products Inc. includes the company’s lab-tested, hemp-extract salves, balms, lotions, essential oils, bath salts, powder packs, oil tinctures, capsules, and gummies. To purchase Alkaline88 and A88 Flavor Infused products online, visit www.Alkaline88.com. To learn more about the company, visit www.TheAlkalineWaterCo.com.

NOTE TO INVESTORS: The latest news and updates relating to WTER are available in the company’s newsroom at http://cnw.fm/WTER

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CannabisNewsBreaks – Sugarmade Inc. (SGMD) Issues Shareholder Update Outlining Growing Nug Avenue Operations, Strides Toward Vertical Integration

Sugarmade (OTC: SGMD), an emerging leader in the vertically integrated cannabis marketplace based in California, today updated current and prospective shareholders on its growing Nug Avenue operations. The update also included progress on the company’s continued strides toward verticalizing its model through the acquisition of California cannabis licenses and potentially establishing commercial operations in the cannabis delivery market outside of the state of California. “We will have more details on Nug Avenue performance soon, but we wanted to report our strong progress and let our shareholders know that we are quickly establishing a brand presence in the Los Angeles cannabis delivery market at our first location, which should carry over to help in establishing rapid customer growth in new locations as we expand,” said Jimmy Chan, Sugarmade CEO. “We continue to make tangible strides toward a vertically integrated model. Our long-term strategic vision is to establish the capacity to control all aspects of production, supply, manufacturing, packaging, distribution and delivery — to become a true ‘farm to door’ cannabis company. This vision should provide for better unit economics, margin growth and gains in product quality and customer satisfaction. Organic brand growth, property acquisition, licensing and geographic expansion are all important steps toward achieving that vision for Sugarmade and its shareholders.”

To view the full press release, visit https://cnw.fm/UnCDm

About Sugarmade Inc.

Sugarmade is a product and branding marketing company investing in operations and technologies with disruptive potential. The company’s brand portfolio includes CarryOutsupplies.com, SugarRush(TM), Nug Avenue, Lemon Glow and Budcars. For more information, please visit www.Sugarmade.com.

NOTE TO INVESTORS: The latest news and updates relating to SGMD are available in the company’s newsroom at http://cnw.fm/SGMD

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HempNewsBreaks – Beard Management Inc. Announces Successful Completion of FDA Inspection

Beard Management, the company behind multiple globally recognized e-liquid brands such as Beard Vape Co. and The One E-liquids, today announced its successful completion of an inspection by the U.S. Food and Drug Administration (“FDA”) as a part of the company’s PMTA application review on July 13 and 14. According to the update, Beard Management is currently in the review phase of its PMTA application, which includes 45 of the company’s most popular e-liquid products, including flavors from the Beard Vape Co. and The One E-liquid brands. In April, Beard announced its retention of Blackbriar Regulatory Services LLC (“BRS”) as its exclusive manufacturer and agent of record with the FDA, overseeing the process of providing the FDA with any additional regulatory and testing work required for Beard’s current PMTAs to scientifically prove its products are appropriate for the protection of public health. “This inspection absolutely reaffirms our decision to use BRS for our regulatory needs,” said Brady Bates, CEO of Beard. “Over the past few months, we have worked with them to prepare for the eventuality of an inspection like this. Thanks to BRS’ in-depth understanding of the PMTA review process and their experience in dealing with FDA inspections, we were very well prepared for what transpired. The successful completion of this inspection further strengthens our market position, our application and our positive relationship with the FDA, and we couldn’t be happier with the outcome.”

To view the full press release, visit https://cnw.fm/w0EpL

About Beard Management Inc.

Beard Management owns and distributes numerous brands across varying categories, including electronic nicotine delivery system products, hemp derivatives and rolling papers. Founded in 2014, Beard remains committed to continuous product development while providing high-quality products to adult consumers. Beard currently services retailers and distributors of every size nationally and in over 30 countries worldwide. To learn more about Beard, visit www.BeardVapeCo.com.

About HempWire

HempWire (HW) is a dedicated information provider focused on (1) aggregating hemp-related news, (2) issuing HempNewsBreaks designed to update investors on the latest developments in the hemp market, (3) enhancing corporate news releases, (4) providing full-service distribution and social media offerings to public and private client-partners and (5) designing and implementing all-inclusive corporate communication solutions. HW is strategically positioned within the rapidly expanding hemp sector with a team of journalists working to help a growing roster of public and private companies reach a wide audience of investors, consumers and members of the media. We leverage a vast network of more than 5,000 key syndication outlets to deliver unparalleled visibility, recognition and content to the hemp industry. HempWire (HW) is where HEMP news, content and information converge.

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CannabisNewsBreaks – Lexaria Bioscience Corp. (NASDAQ: LEXX) Announces Results of Antiviral Drug Studies, Strategy Moving Forward

Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug-delivery platforms, has released a summary of its 2021 antiviral drug program so far this year, noting that all objectives in evaluating its proprietary DehydraTECH(TM) drug-delivery platform have been achieved. In addition, the company also discussed next steps. In short, the company stated thatit has successfully tested and released summary results on five different compounds from three antiviral drug classes, with results gathered that indicate up to a threefold increase in oral drug delivery into the bloodstream upon animal testing when processed with DehydraTECH. According to the announcement, the company has been able to determine whether DehydraTECH processing of compounds from leading classes of antiviral drugs for SARS-CoV-2/COVID-19, HIV/AIDS and other infectious diseases had the ability to exhibit evidence of superior oral absorption relative to controls. In addition, testing has shown whether DehydraTECH processing of those compounds could preserve expected viral inhibitory performance upon efficacy testing in infected mammalian cells. In addition, the company noted that DehydraTECH neither alters nor degrades drug molecules chemically, resulting in the creation of new molecular entities. Looking forward, the company’s drug-testing program will likely include larger in vivo efficacy evaluations in animals infected with SARS-CoV-2, HIV or other infectious viruses. The announcement noted that Lexaria is focused on a comprehensive, multipronged program designed to gather and evaluate proof-of-concept safety, efficacy and formulation/scalability feasibility data for potential pharmaceutical industry partners to evaluate for expanded, collaborative product development.

To view the full press release, visit https://cnw.fm/1kd1y

About Lexaria Bioscience Corp.

Lexaria Bioscience’s proprietary drug-delivery technology, DehydraTECH(TM), improves the way active pharmaceutical ingredients (“APIs”) enter the bloodstream by promoting healthier oral ingestion methods and increasing the effectiveness of fat-soluble active molecules, thereby lowering overall dosing. The company’s technology can be applied to many different ingestible product formats including foods, beverages, oral suspensions, tablets and capsules. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption of cannabinoids and nicotine by up to 5 to 10 times, reduce time of onset from one to two hours to minutes, and mask unwanted tastes; the technology is planned to be further evaluated for orally administered bioactive molecules including anti-viral drugs, vitamins, nonsteroidal anti-inflammatory drugs (NSAIDs) and more. Lexaria has licensed DehydraTECH to multiple companies including a world-leading tobacco producer for the development of smokeless, oral-based nicotine products and for use in industries that produce cannabinoid beverages, edibles and oral products. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 20 patents granted and more than 50 patents pending worldwide. For more information about the company, please visit www.LexariaScience.com.

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420 with CNW — Study Finds Cannabis Terpenes Relieve Pain, Play Role in “Entourage Effect”

Cannabinoids are a range of compounds produced by plants in the cannabis family with THC, the main psychoactive component in marijuana, being the most abundant as well as the most well-known. Most of these compounds, including THC, have been found to have a variety of health benefits, with most of them producing minimal to zero psychoactive effects.

For quite a while, there has been a theory about how cannabis, when consumed as a whole, is much more effective compared to when the cannabinoids are taken separately. Dubbed the “entourage effect,” this theory states that the sum of the cannabis plant, including terpenes and flavonoids as well as cannabinoids is greater than its individual components.

A recent study from the University of Arizona Health Science has uncovered evidence to back this theory, especially regarding cannabis’ pain-relieving capabilities. The researchers found that using cannabinoids alongside terpenes had a much more impactful effect on pain, potentially providing individuals suffering from chronic pain a treatment option that would need fewer doses and result in fewer negative effects.

John Streicher, PhD, the study’s lead researcher and an associate professor of pharmacology at the College of Medicine in Tucson, Arizona, and a member of the UArizona Health Sciences Comprehensive Pain and Addiction Center, says the researchers wanted to see if they could boost THC’s “modest pain-relieving” abilities by leveraging the entourage effect. Terpenes, which are produced by many plants, not just cannabis, and are responsible for marijuana’s pungent aroma, provided interesting results.

The researchers found that cannabis terpenes mimicked cannabinoids when taken by themselves, leading to a moderate level of pain relief. Once they were used together with cannabinoids, their pain-relieving impact was boosted without any negative side effects. Since terpenes can be found in numerous plants, the researchers did not expect them to affect pain the way cannabinoids do, says Streicher, who noted that the researchers used four cannabis terpenes: linalool, beta-pinene, alpha-humulene and geraniol as well as a synthetic cannabinoid capable of stimulating the body’s cannabinoid receptors called WIN55,212-2.

Cannabinoids such as THC interact with the endocannabinoid system, binding to either CB1R or CB2R receptors. According to the researchers, the four terpenes they used attached to the CB1R receptors, with behavioral studies using mice proving that once the terpenes had interacted with the receptors, they caused three of the four classic cannabinoid effects. Those effects were reduced sensitivity to pain, reduced movement, lower body temperature and catalepsy.

Streicher hopes that the research may eventually lend a hand in the fight against the opioid crisis, especially in regard to cancer-related pain. By developing therapies that combine cannabinoids and terpenes, he would like to offer people suffering from different types of cancer-related pain a low-dosage, minimum-risk treatment option.

With the increasing availability of technologies such as the IoT dose-measuring devices being made by RYAH Group Inc. (CSE: RYAH), researchers could find it even easier to study how phtyocannabinoids, terpenes and other compounds affect human health.

NOTE TO INVESTORS: The latest news and updates relating to RYAH Group Inc. (CSE: RYAH) are available in the company’s newsroom at https://cnw.fm/RYAH

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