• Lexaria began its human clinical study on oral nicotine alternatives, evaluating the effectiveness of its DehydraTECH-nicotine pouch performance 
• Earlier in the year, the company also announced the commencement of its HYPER-H21-4 human clinical study on the effectiveness of DehydraTECH-processed CBD for hypertension treatment
• Lexaria has also made some significant progress in the use of its technology for the enhanced delivery of antiviral drugs
• It hopes that before the end of 2022, it will have built sufficient data to effect meaningful industry progress and sustainable increases in valuation

Lexaria Bioscience (NASDAQ: LEXX), since its inception, has been pushing the boundaries of drug delivery. Through its patented technology, DehydraTECH(TM), the company has achieved more efficient delivery of active pharmaceutical ingredients into the bloodstream while also increasing their bioavailability.

Its technology has seen application in pharmaceuticals, nutraceuticals, consumer packaged goods, and over-the-counter capsules, pills, tablets, and oral suspensions. Lexaria has explored its usage in the delivery of cannabinoids, nicotine, antivirals, PDE5 inhibitors, and more.

In March 2022, the company announced that it would begin a human clinical study, NIC-H22-1, focused on oral nicotine alternatives to replace smoking. The study would involve 36 participants and compare DehydraTECH’s nicotine pouch performance with existing brands on the market. In a previous animal study, the DehydraTECH-nicotine proved to deliver peak nicotine performance to the bloodstream 10 to 20 times faster than the study’s controls (https://cnw.fm/dxNJC). 

Lexaria is also in the process of a clinical human study, HYPER-H21-4, to determine the effectiveness of DehydraTECH-CBD for hypertension treatment. Involving 60 participants, this ranks as one of the most comprehensive studies undertaken by Lexaria and is a significant step for the company as it seeks Investigational New Drug (“IND”) approval by the United States Food and Drug Administration (“FDA”). Results are expected in Q3 2022 (https://cnw.fm/ZuBWv). 

Lexaria has also made significant progress using its technology for the enhanced delivery of antiviral drugs. On April 26, 2022, it received its 25th patent granted worldwide in what Chris Bunka, the Chief Executive Officer (“CEO”) of the company, referred to as “Another validation of the versatility of our DehydraTECH drug delivery technology” (https://cnw.fm/6FEzS). 

Earlier in the year, Lexaria also announced commencing the first phase of its epilepsy research program, EPIL-A21-1. The study would assess the seizure-inhibiting activity of CBD administered via the company’s DehydraTECH technology. More specifically, Lexaria aimed to compare its technology to the only FDA-approved CBD-based seizure medication Epidiolex, used to treat seizures associated with two rare forms of pediatric epilepsy- Lennox-Gastaut syndrome and Dravet syndrome (https://cnw.fm/0nkiX). 

All of Lexaria’s efforts serve to demonstrate the superior performance of both its research program and its DehydraTECH drug delivery technology. By doing so, it is looking to tap into various markets, including but not limited to oral cannabinoids, oral mucosal nicotine, antivirals, human hormones, dementia, rheumatoid disease and diabetes. 

Lexaria’s management hopes that before the end of the 2022 calendar year, it will have built sufficient data to effect meaningful industry progress and sustainable increases in valuation to steer the conversation forward and allow for the greater adoption of DehydraTECH.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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Lexaria Bioscience Corp. (NASDAQ: LEXX) is expected to begin dosing for the NIC-H22-1 human study this summer. “NIC-H22-1, a pharmacokinetic randomized, double-blinded, cross-over study involving 36 human participants, will compare Lexaria’s DehydraTECH-nicotine pouch performance to that of existing leading brands available to U.S. customers, namely ON! and Zyn,” a recent article reads. The human study NIC-H22-1 is expected to build on the successes of the company’s animal studies, which have proven the technology’s effectiveness in promoting faster absorption, higher peak absorption, and greater overall quantities of nicotine, on average, in the blood than concentration-matched control formulations. “In 2021, the company announced its oral nicotine absorption study, NIC-A21-1, revealing that DehydraTECH-oral nicotine delivery peaked in the bloodstream 10x to 20x faster than controls, and peak levels achieved were up to 10x higher than controls. ‘Performance gains of this magnitude could be of great significance in enabling the oral pouch product category to offer improved nicotine satiety and effectiveness, with a goal of one day rendering pulmonary administration practices like smoking and vaping as obsolete,’ Lexaria CEO Chris Bunka said of last year’s outstanding results.”

To view the full article, visit https://cnw.fm/OZuaK

About Lexaria Bioscience Corp.

Lexaria’s patented drug delivery technology, DehydraTECH(TM), improves the way active pharmaceutical ingredients (“APIs”) enter the bloodstream by promoting more effective oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids and nicotine by up to 5-10x, reduce time of onset from 1 – 2 hours to minutes, and mask unwanted tastes; and is also being evaluated for orally administered anti-viral drugs, non-steroidal anti-inflammatory drugs (“NSAIDs”), PDE5 inhibitors and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 25 patents granted and over 50 patents pending worldwide. For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• In its most recent oral nicotine study, Lexaria established that DehydraTECH-oral nicotine delivery peaked in bloodstream 10x to 20x faster than controls and peak levels achieved were up to 10x higher than controls
• Lexaria hopes to evidence in its upcoming human oral nicotine study NIC-H22-1, that processing purified nicotine with DehydraTECH leads to better oral-tissue absorption and reduced negative experiences compared to currently sold brands
• Lexaria’s DehydraTECH technology works with new and existing drugs, processing them into a final form that increases bioavailability, speeds up onset and improves effectiveness that can allow for smaller doses 
• The company also recently announced new agreements with tobacco giant Altria for evaluation of some of its powder-based nicotine formulations

Technology innovator Lexaria Bioscience (NASDAQ: LEXX) has developed a drug delivery technology designed to increase bio-absorption, reduce time of onset and mask unwanted tastes of a wide variety of medicines and therapeutics. 

In exploring the potential of its patented DehydraTECH(TM) technology, which uses a proprietary process to render active pharmaceutical ingredients into a readily absorbable final form, Lexaria has investigated DehydraTECH’s effectiveness in various markets such as hypertension, antivirals and oral nicotine to name a few, with outstanding results. 

Another important area of study has focused on nicotine alternatives to replace smoking. This summer, the Company will begin a human clinical study, NIC-H22-1, which will dose a minimum of 36 people to compare Lexaria’s DehydraTECH-nicotine pouch performance with that of existing brands such as ON! and Zyn currently sold in the United States, drawing on existing capital to fund the study (https://cnw.fm/WtaDW). Animal testing has already demonstrated that DehydraTECH-nicotine can deliver peak nicotine performance to the bloodstream 10 to 20 times faster than the study’s controls (https://cnw.fm/mgn96). 

In March, the company received its first ever patent granted to use DehydraTECH to deliver nicotine more efficiently through buccal tissue absorption in Australia (https://cnw.fm/ZSXqk). Buccal tissue is the type of tissue in your mouth and throat, allowing for the nicotine to be primarily absorbed before it enters the stomach. Similar patent filings have been made in the U.S. and in the EU and Lexaria believes those potential patent awards could support significant competitive advantages in the nicotine white pouch category, as well as other oral nicotine product formats. 

The FDA has long resisted formal authorization of smokeless alternatives to tobacco consumption because of concerns about their capacity to lure youths into addiction. 

“Anyone who does not currently use tobacco products, especially youth, should refrain from doing so,” Acting FDA Commissioner Ned Sharpless, M.D., said in relation to the agency’s authorization for some “Modified Risk Tobacco Products” to be marketed as a safer alternative to smoking in recent months. But in 2019, Swedish smokeless brand General became the first in the long history of the FDA to ever win that marketing allowance. (https://cnw.fm/eH7IZ).

Lexaria has long held that any form of inhaling chemical substances can be detrimental to health, and its DehydraTECH-nicotine aims to help vapers as well as smokers wean themselves off of those products, giving them relief from cravings while offering a safer nicotine alternative.

“My father also died from lung cancer … so I am no fan (of smoking),” CEO Chris Bunka told Forbes in 2019 (https://cnw.fm/yinGr). “The fact that (DehydraTECH) is fast means that smokers might not be frustrated waiting for their nicotine experience to begin, the way they have been with traditional nicotine products such as gums and lozenges.”

The company is working with the tobacco industry, and recently announced new agreements with tobacco giant Altria Client Services, LLC in which Lexaria will receive a fee to provide certain DehydraTECH powder-based nicotine formulations to Altria for evaluation (https://cnw.fm/y2LmV).

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• Lexaria received its 25th patent – and the first patent for the use of DehydraTECH technology in the enhanced delivery of antiviral drugs
• The company is seeking IND approval from the FDA and has commenced its human HYPER-H21-4 study for hypertension with DehydraTECH-CBD, with results expected in Q3 2022
• Lexaria is also commencing its human oral nicotine study, NIC-H22-1 to compare Lexaria’s DehydraTECH-nicotine pouch performance to that of existing leading brands currently sold in the US such as ON! and Zyn

Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, has announced some positive news that further promotes the company’s goal of creating innovative drug delivery alternatives with its proprietary patented DehydraTECH(TM) technology. Lexaria is making the delivery of drugs quicker, more efficient, and even tasting better.

The company was granted its 25th patent – the first received for the use of its DehydraTECH technology for the enhanced delivery of antiviral drugs. The official word was received from the United States Patent and Trademark Office that on April 26, 2022, patent 11,311,559 for Compositions and Methods For Enhanced Delivery of Antiviral Agents would be issued to Lexaria.

“This will be our 25th patent granted worldwide and another validation of the versatility of our DehydraTECH drug delivery technology. This new patent adds to our existing suite of granted patents in the EU, the U.S., India, Japan, and Australia, and continues to build value for Lexaria shareholders and clients,” CEO Chris Bunka explained (https://cnw.fm/PnkiP).

Lexaria is also working on various clinical trial studies, including the recently announced HYPER-H21-4 study. HYPER-H21-4 is a randomized, double-blinded, placebo-controlled, cross-over study in 60 people and also one of the most comprehensive studies taken on by the company. Outcomes for the new study are expected to be available in Q3 2022, and the research is a big step for the company seeking IND (investigational New Drug) approval from the FDA.

Moving forward with the HYPER-H21-4 study was motivated by positive findings in the company’s three other human hypertension clinical studies, which has further supported the pursuit of FDA approval. The studies conducted thus far with hypertension and DehydraTECH have yielded positive results in terms of safety and efficacy (https://cnw.fm/AU4pU) as well as reducing blood pressure (https://cnw.fm/02nuE) and arterial stiffness (https://cnw.fm/lq6wk). All of the past study participants have tolerated DehydraTECH-CBD well, with no adverse effects.

Additionally, Lexaria plans to move forward in dosing for their human NIC-H22-1 study this summer. The study is focused on the oral absorption of nicotine and the comparison will be made between the company’s DehydraTECH-nicotine pouch and other popular products on the market like Zyn and ON! The purpose of the study is to support a safe alternative to harmful pulmonary nicotine application processes.

The company’s DehydraTECH technology works to:

• Speed up drug delivery
• Increase bioavailability
• Increase brain absorption
• Improves drug potency
• Reduce drug administration costs
• Mask unwanted tastes

The company has been advancing its technology since 2016 to demonstrate that bio-absorption of drugs like cannabinoids or nicotine can be five to ten times more effective with a reduced onset time. Lexaria also plans to investigate other markets in 2022 (https://cnw.fm/rafiI).

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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Lexaria Bioscience Corp. (NASDAQ: LEXX) is aware of the need to continuously improve its understanding of the capabilities and potential applications of its patented DehydraTECH(TM) drug delivery technology. This informs its long-held commitment to its applied research and development (“R&D”) programs. “So far, the company’s research journey has involved a series of controlled and well-designed in vitro preclinical testing and in vivo animal and human clinical studies…. Still, Lexaria is unrelenting in its pursuit of comprehensive datasets that would answer many questions the company expects to face from potential commercial partners or regulators and is, in fact, expanding its research. [In March], Lexaria kicked off an animal study to evaluate DehydraTECH-CBD as a potential treatment to inhibit seizure activity, the first in a series of additional planned animal studies tentatively set to commence this year,” a recent article reads. “‘DehydraTECH is not an EVOLUTION of existing technology – it is a REVOLUTIONARY new drug delivery platform. Expecting entire industries to change overnight to adopt a revolutionary process is not realistic: it takes time, evidence, and a lot of positive results to overcome industry inertia. We have long been hopeful that, before the end of 2022, we will have built sufficient data to effect meaningful industry and/or regulatory progress and sustainable increases in valuation,’ Lexaria CEO Chris Bunka wrote in a recent letter to shareholders.”

To view the full article, visit https://cnw.fm/dHpXY

About Lexaria Bioscience Corp.

Lexaria’s patented drug delivery technology, DehydraTECH(TM), improves the way active pharmaceutical ingredients (“APIs”) enter the bloodstream by promoting more effective oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids and nicotine by up to 5-10x, reduce time of onset from 1 – 2 hours to minutes, and mask unwanted tastes; and is also being evaluated for orally administered anti-viral drugs, non-steroidal anti-inflammatory drugs (“NSAIDs”), PDE5 inhibitors and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 25 patents granted and over 50 patents pending worldwide. For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• Global drug delivery innovator Lexaria Bioscience is researching the ability of its patented DehydraTECH(TM) technology to improve the performance of a number of prescription drugs 
• Lexaria is a world leader in the investigation of a DehydraTECH-processed cannabidiol (“CBD”) to potentially treat high blood pressure (hypertension), and study outcomes thus far have rendered positive results on effectiveness and patient tolerance
• The company is building a scorecard of data to support its planned FDA application for formal, registered clinical testing under the Investigational New Drug (“IND”) process
• Lexaria recently completed all data analyses of its HYPER-H21-3 study examining DehydraTECH-CBD’s ability to reduce pulmonary artery systolic pressure, and launched HYPER-H21-4 to gather a variety of data points related to DehydraTECH-CBD’s use over a more extensive period of time

High blood pressure has long been labeled “the silent killer” because of its propensity to lead to incapacitating or prematurely deadly strokes, heart attacks and other serious disease indications without necessarily foreshadowing pain or great discomfort. According to the World Health Organization (“WHO”), an estimated 1.28 billion adults aged 30-79 years worldwide have hypertension but only about 1 in 5 (21 percent) people with the condition have it under control with medical treatment (https://cnw.fm/jDeE3). 

During the past decade within the United States, about 49 percent of the population reported taking at least one prescription medication in the past 30 days in data sampling collected by the National Center for Health Statistics of the Centers for Disease Control and Prevention at selected times, while 24 percent of the individuals took three or more prescriptions and 13 percent took five or more (https://cnw.fm/dQJac).

The data showed a marked increase over those persons sampled during the late 1980s to mid-1990s, particularly where multiple medications were concerned. And yet, a recent news report states that as few as 50 percent of patients take their medications exactly as prescribed (https://cnw.fm/pjMQN).

Global drug delivery innovator Lexaria Bioscience (NASDAQ: LEXX) is devoting its research and product development to making drug substances more effective in their approach to treating medical conditions such as high blood pressure and, in the process, to overcoming many of the obstacles that may hinder their proper use by patients. 

The company’s patented DehydraTECH(TM) technology combines an active pharmaceutical ingredient (“API”) with a fatty acid oil and performing a patented dehydration synthesis process before ingestion The Company has demonstrated significant improvements of absorption into bloodstream and even into brain tissue, in as little as minutes after ingestion.

One area of Lexaria’s research has focused on pursuing U.S. Food and Drug Administration (“FDA”) approval to begin formal, registered clinical testing of its DehydraTECH-processed cannabidiol (“CBD”) for the treatment of hypertension under the Investigational New Drug (“IND”) process.

Lexaria recently announced the launch of its HYPER-H21-4 randomized, double blinded, placebo-controlled, cross-over study of DehydraTECH-CBD in relation to  hypertension, with the potential for enhancing Lexaria’s ability to treat cardiovascular and other disease states beyond hypertension that are related to increased arterial stiffness (https://cnw.fm/Wg5qZ).

Lexaria has already completed other human studies. Last year, studies HYPER-H21-1 (https://cnw.fm/qGvMi) and HYPER-H21-2 (https://cnw.fm/Na1s4) provided evidence that DehydraTECH-CBD successfully reduced blood pressure in similarly hypertensive human volunteers, and Lexaria announced earlier this month that it had completed all data analyses of its HYPER-H21-3 study with positive safety and efficacy findings (https://cnw.fm/nFuNt).

HYPER-H21-3 used a placebo-controlled and double-blinded design with 16 volunteers, safely simulating hypoxia conditions (reduced oxygen availability) to induce lung artery constriction, or pulmonary hypertension, to analyze the ability of DehydraTECH-CBD to reduce pulmonary artery systolic pressure. 

HYPER-H21-4 will include 60 people and will be the most comprehensive study Lexaria has conducted to date. Dosing in more than half the volunteers has already begun and all treatment visits are expected to be finished by early July. 

The volunteers are between the ages of 40 and 70 with documented or measured elevated blood pressure, mild hypertension or moderate (stage 2) hypertension. The participants will use an escalating dose of DehydraTECH-CBD every day for a 5-week duration, establishing data for DehydraTECH-CBD’s extended use over time and providing secondary data outcomes that may ultimately lead to additional applications for DehydraTECH-CBD, according to the company. 

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

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• Lexaria expects to begin dosing this summer as part of a human nicotine study, NIC-H22-1, to compare DehydraTECH-nicotine pouch performance to that of existing leading brands such as ON! and Zyn
• So far, the company’s animal studies have evidenced that the technology delivers outstanding results, including faster delivery, an increase in the quantity of peak nicotine delivered, higher brain levels of nicotine, and enhanced bioavailability
• In its most recent study, Lexaria established that DehydraTECH-oral nicotine delivery peaked in bloodstream 10x to 20x faster than controls and peak levels achieved were up to 10x higher than controls
• Lexaria’s research aims to support a safe alternative to the harmful, antiquated pulmonary nicotine administration practices, which claim 7.7 million lives annually 

Since commencing in vivo studies evaluating its DehydraTECH technology for oral nicotine applications in 2018, global innovator Lexaria Bioscience (NASDAQ: LEXX) has primarily focused on animal studies that have proven the technology’s effectiveness in promoting faster absorption, higher peak absorption, and greater overall quantities of nicotine, on average, in the blood than concentration-matched control formulations. Building on the successes of these animal studies, Lexaria has now set its sights on a human nicotine study, NIC-H22-1, which is expected to begin dosing this summer (https://cnw.fm/4KP6s). 

NIC-H22-1, a pharmacokinetic randomized, double-blinded, cross-over study involving 36 human participants, will compare Lexaria’s DehydraTECH-nicotine pouch performance to that of existing leading brands available to US consumers, namely ON! and Zyn. The study primarily aims to collect data on the maximum concentration of nicotine in the bloodstream (“Cmax), the time at which Cmax was reached (“Tmax”), and the area under the (“AUC”) – a parameter that indicates the total quantity of nicotine delivered over time – relative to controls. In addition, as part of its secondary objectives, the study NIC-H22-1 will include extensive subjective evaluations related to, among other things, the user experience and throat burn.

Ultimately, Lexaria hopes to evidence that DehydraTECH-processed purified nicotine improves oral tissue absorption and reduces negative experiences compared to brands currently sold to consumers.

Lexaria’s first animal study, whose results the company announced in April 2018, revealed that DehydraTECH delivered significant nicotine absorption performance improvements relative to controls. These included: 1,160% faster delivery of equivalent quantities of nicotine; 148% uptick in the quantity of peak nicotine delivered to the bloodstream; 560% higher brain levels of nicotine; enhanced bioavailability as evidenced by lower urine levels of nicotine; and lower quantities of key liver metabolites in the bloodstream, suggesting bypass of first-pass liver metabolism (https://cnw.fm/gKvXS).

Later in August 2018, Lexaria announced the results of an animal study showing the company had successfully delivered nicotine in an edible form into the blood plasma a few minutes after dosing. Notable highlights from the study included a 79% improvement in Cmax; a 94% enhancement in AUC, a 70% improvement, on average, in the speed of delivering the nicotine; and significantly greater absorption levels. According to Lexaria, this study corroborated and confirmed the validity of the April 2018 results (https://cnw.fm/3YNWB). 

In 2021, the company announced its oral nicotine absorption study, NIC-A21-1, revealing that DehydraTECH-oral nicotine delivery peaked in bloodstream 10x to 20x faster than controls and peak levels achieved were up to 10x higher than controls (https://cnw.fm/ZnyOZ).

“Performance gains of this magnitude could be of great significance in enabling the oral pouch product category to offer improved nicotine satiety and effectiveness, with a goal of one day rendering pulmonary administration practices like smoking and vaping as obsolete,” Lexaria CEO Chris Bunka said of last year’s outstanding results.

Through its focus on oral nicotine products as well as its ever-growing portfolio of in vivo studies, Lexaria’s research aims to support a safer, more effective nicotine alternative to 1.1 billion smokers worldwide (as of 2019). With tobacco causing 1 in 5 deaths in males globally and roughly 7.7 million cumulative deaths annually (https://cnw.fm/H2Gyr), Lexaria’s DehydraTECH technology, which has so far delivered outstanding results in animals, could help the millions of users move away from the harmful smoking habit. And the upcoming human study is expected to inch the company closer to realizing this goal. In fact, Lexaria is optimistic this larger human study will produce positive findings pursuant to those evidenced by the 2021 study. 

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

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• Lexaria’s patented DehydraTECH(TM) technology has proven, in the NIC-A21-1 animal study, to be 10-20 times faster in reaching peak delivery of nicotine to the bloodstream than controls
• The company hopes to affirm this in the NIC-H22-1 human nicotine study as their DehydraTECH-nicotine pouch performance will be compared to existing leading brands currently sold in the United States such as ON! and Zyn
• Lexaria has separately announced new agreements with Altria that will see the company receive a fee to provide certain DehydraTECH powder-based nicotine formulations that Altria will evaluate
• The company hopes that this, coupled with the human clinical study, will confirm that purified nicotine with DehydraTECH leads to better oral tissue absorption and reduced negative experiences relative to existing brands

Lexaria Bioscience (NASDAQ: LEXX) has made a name for itself as a global innovator in drug delivery platforms. Its patented DehydraTECH(TM) technology, promotes fast-acting, less expensive, and more effective oral drug delivery, proven through in vivo, in vitro, and human clinical testing.

So far, Lexaria has filed for patent protection for specific delivery of vitamins, NSAIDs, estrogen, cannabinoids, testosterone, PDE5 inhibitors, and terpenes, among others. However, one product that stands out is nicotine. 

Since developing DehydraTECH back in 2014, the company has been pushing for its application to most oral forms of nicotine, including but not limited to tablets, capsules, pouches, sprays, gums, pills, and lozenges. Earlier this year, the company was granted a new Australian patent that recognized DehydraTECH’s superiority in oral nicotine delivery, including in free base nicotine, nicotine salts, polymer resins of nicotine, and other forms of nicotine complexes (https://cnw.fm/hUVAr).

In 2021, Lexaria demonstrated that oral nicotine pouches using DehydraTECH technology were 10 to 20 times faster in reaching peak nicotine delivery to the bloodstream than controls, taking advantage of the new oral nicotine patent award. This animal study NIC-A21-1 showed the technology’s potential, which the company hopes will be affirmed in the NIC-H22-1 human nicotine study set to begin dosing in the summer of 2022 (https://cnw.fm/8cD79).

In another significant milestone for the company’s nicotine field of study, Lexaria announced having entered into new agreements with Altria Client Services, LLC. These agreements will see Lexaria receive a fee to provide certain DehydraTECH powder-based nicotine formulations, which will be evaluated by Altria (https://cnw.fm/k88mg).

With this, coupled with the NIC-H22-1 study, Lexaria hopes to evidence that purified nicotine with DehydraTECH leads to better oral-tissue absorption and reduced negative experiences, particularly when compared to brands that are currently in the market. 

In 2018, the global smokeless tobacco products market was valued at $13.6 billion. By 2025, it is projected that this industry will have posted a 7.2% annual growth. Specifically, the global market for oral nicotine pouches stood at $2.33 billion in 2020. Furthermore, it is projected that by 2027, this sector will be valued at $21.84 billion, representing a CAGR of 30.7%.

Lexaria plans to capitalize on this growth and the company’s management is confident that the investments made thus far will pay off significantly as time progresses.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

To receive instant SMS alerts, text “Cannabis” to 844-397-5787 (U.S. Mobile Phones Only)

For more information please visit https://www.CannabisNewsWire.com

Please see full terms of use and disclaimers on the CannabisNewsWire website applicable to all content provided by CNW, wherever published or re-published: http://CNW.fm/Disclaimer

Do you have questions or are you interested in working with CNW? Ask our Editor

CannabisNewsWire (CNW)
Denver, Colorado
www.CannabisNewsWire.com
303.498.7722 Office
Editor@CannabisNewsWire.com

CannabisNewsWire is part of the InvestorBrandNetwork.