• Lexaria’s human oral nicotine study, NIC-H22-1, comparing world-leading brands and the company’s DehydraTECH(TM)-Nicotine tobacco-free pouch, reported positive results, including higher pleasurable effects and reduced negative effects
• A new patent has been granted to Lexaria and is strategically important to the company’s oral nicotine sector research and development efforts
• Lexaria continues to research diabetes control and weight loss with its DehydraTECH(TM)-CBD, announcing favorable animal study results and the intent to develop a human clinical study

Lexaria Bioscience (NASDAQ: LEXX, LEXXW), a global innovator in drug delivery platforms, has announced updates regarding its patented DehydraTECH(TM) technology – which improves the way that active pharmaceutical ingredients (“APIs”) enter the bloodstream by promoting healthier oral ingestion methods and increasing the effectiveness of fat-soluble active molecules. Lexaria’s primary focus for DehydraTECH research and development includes advancements of product candidates across key segments, including nicotine replacement, diabetes control and weight loss, and hypertension.

The company’s most recent announcement reported results from its 2023 human oral nicotine study NIC-H22-1, comparing Lexaria’s DehydraTECH(TM)-Nicotine tobacco-free pouch to world-leading brands ZYN(R) and on!. Using measurements to determine the median time required to reach comparable nicotine concentrations within the bloodstream (“Tmax”), Lexaria exhibited higher levels of certain pleasurable effects over the competition. DehydraTECH also provided the lowest frequency of unwanted negative effects, including moderate to severe nausea, demonstrating benefits from Lexaria’s formulation.

In addition to the announcement of favorable results from its NIC-H22-1 study, the company was recently granted a strategically important new patent in the oral nicotine sector by the United States Patent and Trademark Office, US Patent #11,700,875 Compositions and Methods for Sublingual Delivery of Nicotine. This new patent builds upon the company’s growing portfolio of 35 granted patents, with several more pending worldwide – spanning Lexaria’s research and development focus.

“We’ve always had an overwhelming determination and fierce conviction that we can make the world a better place and reduce the carnage caused by smoked cigarettes, and now we have human study data that demonstrates advantages of DehydraTECH processed nicotine relative to the competitive landscape,” said Chris Bunka, CEO of Lexaria (https://cnw.fm/8CwPl).

Separately, Lexaria also intends to conduct a human clinical study to examine its DehydraTECH-CBD formulation for diabetes control and weight loss. This intent comes after positive results were released in early August regarding its DIAB-A22-1 study in obese diabetic-conditioned animals, which achieved the following:

• Lowered blood glucose levels by 19.9% (p<0.05)
• Lowered overall body weight by 7% sustained over eight weeks
• Witnessed a statistically significant increase in locomotor activity (p<0.05)
• Lowered triglyceride levels by more than 25% (p<0.007)
• Lowered blood urea nitrogen levels by 27.9% (p<0.001)

These successful pre-clinical results have the company determined to undertake a human study to investigate whether these improvements are also evidenced in humans. The study design is currently underway and will be submitted to an independent review board for approval.

As the company continues to grow and explore maximizing the potential of its DehydraTECH technology, a new wholly-owned subsidiary under the name Lexaria Nutraceutical Corp. (“LEXX Nutra”) has been formed. LEXX Nutra has been granted an exclusive, perpetual license entitling it to use DehydraTECH, or sublicense the use of DehydraTECH, to create consumer packaged goods and/or intermediate ingredients composed of any molecule except those associated with cannabis or nicotine. LEXX Nutra is also prohibited from using its licensing to manufacture any pharmaceutical product.

Lexaria Pharmaceutical Corp.’s licensing was also amended, ensuring it would only focus on manufacturing pharmaceutical products–excluding nicotine-associated molecules. The formation of Lexaria’s wholly-owned subsidiaries draws a distinct line in the sand for Lexaria, ensuring that proper research and development efforts for key indications are being diverted to the appropriate subsidiary.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

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• Lexaria’s patented DehydraTECH(TM)-CBD achieved promising results for diabetes control and weight loss in animals during the pre-clinical animal study DIAB-A22-1
• The weight loss drug market was valued at $1.90 billion in 2021 and is expected to reach $13.26 billion by 2029, growing at a CAGR of 24.7%
• Many drugs used to control diabetes have produced results in managing obesity, which Lexaria plans to leverage with its DehydraTECH(TM) technology

Lexaria Bioscience (NASDAQ: LEXX, LEXXW), a global innovator in drug delivery platforms, recently announced its intent to conduct a human clinical study to examine its patented DehydraTECH(TM)-processed cannabidiol (“CBD”) for diabetes control and weight loss. The company has already completed a pre-clinical diabetes study in animals, which supports its advancement to human trials for diabetes control and weight loss (https://cnw.fm/H1XXZ).

Lexaria had announced in two prior press releases, on March 2 and June 16, that its pre-clinical diabetes study DIAB-A22-1 in obese diabetic-conditioned animals, that DehydraTECH-CBD had achieved the following:

• Lowered blood glucose levels by 19.9% (p<0.05)
• Lowered overall body weight by 7% sustained over eight weeks
• Witnessed a statistically significant increase in locomotor activity (p<0.05)
• Lowered triglyceride levels by more than 25% (p<0.007)
• Lowered blood urea nitrogen levels by 27.9% (p<0.001)

Based on these successful pre-clinical results, the management of Lexaria has decided to undertake a human diabetes clinical study to investigate whether any of these improvements will also be evidenced in humans. Lexaria is currently designing the study, which will be followed by submission to an independent review board to gain necessary approvals.

According to the Centers for Disease Control (“CDC”), managing one’s blood sugar levels is important to avoid diabetes-related conditions, including vision loss, heart disease, and kidney disease (https://cnw.fm/cgbJX). Generic CBD studies, mainly conducted in animals, indicate that it may be ineffective in controlling blood sugar. Lexaria hopes to study whether the DehydraTECH-CBD formulation provides additional insight into human blood sugar control. The company is encouraged by DehydraTECH-CBD’s ability to reduce animal blood sugar levels and believes it warrants additional investigation.

The DehydraTECH technology is designed specifically for formulating and delivering lipophilic (fat-soluble) drugs and active pharmaceutical ingredients (“APIs”). DehydraTECH increases effectiveness and improves the way these APIs enter the bloodstream. The benefits of ingesting a DehydraTECH-enabled drug or consumer product include the following:

• Speeds up delivery with effects of the product felt in minutes
• Increases bioavailability due to its effectiveness in delivering a drug into the bloodstream
• Increases brain absorption, with animal testing evidencing higher drug quantities delivered across the blood-brain barrier
• Improved drug potency, with more of the drug available to the body, requiring lower dosages
• Reduced drug administration costs, meaning that lower dosages require less drug cost overall
• Mask unwanted tastes and reduces or eliminate the need for sweeteners

The company has also collaborated with the National Research Council (“NRC”), the Canadian government’s premier research and technology organization. DehydraTECH is covered by over 30 granted patents, with more pending worldwide. The patent protection includes formulations for specific delivery of cannabinoids, antiviral drugs, nicotine and more.

Many drugs used to control human blood glucose levels have shown promising weight loss results. The weight loss drug market was valued at $1.90 billion in 2021 and is expected to reach $13.26 billion by 2029, growing at a CAGR of 24.7% (https://cnw.fm/of7Pg). The market is growing due to the public’s growing interest in how obesity contributes to other health problems. Lexaria is positioning itself to potentially penetrate this market with its human-based clinical trial of DehydraTECH-CBD and diabetes control.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

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• Lexaria recently celebrated the receipt of its 35th overall granted patent worldwide when the USPTO recently awarded US patent #11,700,875, titled “Compositions and Methods For Sublingual Delivery of Nicotine”
• The company described the new patent as “strategically important”
• The patent positions the company to tap into the growing oral nicotine market and offers protection in one of the world’s leading oral nicotine markets
• This patent could also lead to additional subsequent patents from within this family
• Lexaria’s DehydraTECH-nicotine formulation is patent granted for oral nicotine delivery in the US, Canada, and Australia

When Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, announced receipt of an Australian patent on March 8, 2022 (https://cnw.fm/41v9c), its resolve to continue expanding its intellectual property (“IP”), particularly within the oral nicotine sector, received a significant boost. The then-new Australian patent had expanded upon the company’s IP rights to apply its DehydraTECH(TM) technology platform to most oral forms of nicotine. Still, the company intended to continue growing its existing portfolio, expanding IP protection to multiple other jurisdictions.

Motivated, Lexaria filed a new patent application with the United States Patent and Trademark Office (“USPTO”) shortly thereafter on March 22. And, more than a year later, the application has proven successful, with the company recently celebrating the receipt of the patent granted, US patent #11,700,875, titled “Compositions and Methods For Sublingual Delivery of Nicotine” (https://cnw.fm/YXHoS). 

The new US patent covers various forms and sources of nicotine, including nicotine benzoate, nicotine polacrilex, nicotine citrate, nicotine detartrate, and many others, for use in sublingual delivery formats like oral pouches. And while the title alludes to sublingual delivery, the patent document published by the USPTO discloses that “the terms ‘sublingual’ and ‘buccal’ are used interchangeably… Therefore, the disclose compositions can be absorbed in any manner chosen by the user” (https://cnw.fm/8tkwr).

The new US patent is remarkable and “strategically important” in many ways. First, it is the company’s 35th overall granted patent worldwide and the 13th granted in the United States. Second, a total of 30 claims were awarded within this patent, the highest number of claims accepted by the USPTO in the company’s existing portfolio. And with researchers agreeing that patents with a higher number of claims are better protected and can be an important measure of a patent’s value (https://cnw.fm/aL8L9), the claims increase the value of the new patent and perhaps even the company’s entire IP portfolio.

Third, and as the company wrote in its March 2022 press release, “At times in Lexaria’s history, the granting of a first patent in a new patent family has led to additional subsequent patents from within that same family,” the new US patent could lead to the award of patents within this family in other countries. In fact, this statement was confirmed recently, albeit with a different patent family. In June, Lexaria announced it had been granted a new Canadian patent under Patent Family #8: “Compositions Infused with Nicotine Compounds and Methods of Use Thereof,” the second within this family after the Australian patent granted last year (https://cnw.fm/Brwvw).

Moreover, the new patent grants IP protection within the United States, one of the world’s leading oral nicotine markets, according to an analysis by the Foundation for a Smoke-Free World (https://cnw.fm/SgsJR). The US nicotine pouches market is projected to grow at a 33% CAGR between 2023 and 2030 (https://cnw.fm/Rgh6F).

But beyond the United States, and given that the company’s DehydraTECH-nicotine formulation is also patent granted for oral nicotine delivery in Canada and Australia, with numerous applications pending in other jurisdictions, Lexaria is ideally positioned to tap into the growing global oral nicotine market. Analysts at Market Research project the global nicotine pouches market to grow at a 13.4% CAGR between 2023 and 2029, reaching a value of $11.91 billion at the end of the forecast period, up from $4.69 billion in 2022 (https://cnw.fm/aRnDl).

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• Lexaria Nutraceutical Corp. will keep Lexaria’s overall strategy of maximizing the company’s patented DehydraTECH(TM) technology in various markets, excluding pharmaceutical, nicotine, and cannabis molecules
• Lexaria Pharmaceutical Corp.’s licensing was amended so as to solely focus on pharmaceutical formulations excluding nicotine
• Lexaria announced in early May that its nicotine trial, NIC-H22-1, had completed dosing with results expected in the near future
• NIC-H22-1 is anticipated to intercede the oral nicotine pouch market, which had a global value of $2.33 billion in 2020, and is expected to grow to $21.84 billion by 2027

Lexaria Bioscience (NASDAQ: LEXX, LEXXW), a global innovator in drug delivery platforms, recently announced the incorporation of a new wholly-owned subsidiary under the name Lexaria Nutraceutical Corp. (LEXX Nutra). LEXX Nutra will keep with Lexaria’s overall strategy of maximizing the company’s patented DehydraTECH(TM) technology in various markets. Lexaria has issued an exclusive, perpetual license to LEXX Nutra, allowing the use of DehydraTECH to create consumer packaged goods and/or intermediate ingredients composed of molecular compounds except those associated with nicotine or cannabis (https://cnw.fm/aLnFI).

LEXX Nutra is also prohibited from using the licensing agreement for the manufacturing of any pharmaceutical product. Lexaria’s other wholly-owned subsidiary, Lexaria Pharmaceutical Corp. (LEXX Pharma), has had its licensing amended so that its sole focus is on manufacturing pharmaceutical products composed of any molecule except nicotine-associated molecules.

Lexaria additionally announced at the beginning of May that its human oral nicotine study, NIC-H22-1, has completed dosing. Data amalgamation and analysis have been ongoing, and Lexaria expects to be able to release results in the coming weeks. NIC-H22-1 is a human pharmacokinetic randomized, double-blinded, cross-over study conducted in a minimum of 36 human volunteers that currently smoke cigarettes. The global oral nicotine pouch market was valued at $2.33 billion in 2020 and is growing at a CAGR of 30.7%, expected to result in a value of $21.84 billion by 2027 (https://cnw.fm/0B5LT).

Lexaria is focused on the ongoing research and development efforts of product candidates across multiple segments, including hypertension, oral nicotine, antivirals, epilepsy, human hormones, PDE5 inhibitors, and more. The company’s DehydraTECH was designed to formulate and deliver fat-soluble drugs and active pharmaceutical ingredients to increase effectiveness and improve how active pharmaceutical ingredients enter the bloodstream. The major benefits of ingesting a DehydraTECH-enabled drug or consumer product include the following:

• A faster delivery time, with effects felt in minutes
• Increased bioavailability, with more of the drug entering the bloodstream
• Increased brain absorption, with animal testing that suggests a significant improvement in the quantity of the drug being delivered across the blood-brain barrier
• Improved drug potency, with more of the ingested product being made available to the body, requiring lower dosages for the desired outcome
• Reduced drug administration costs, with lower dosages, meaning less cost overall
• The masking of unwanted tastes, which eliminates the use of unnecessary sweeteners

DehydraTECH is covered by 35 granted patents, with several pending worldwide, with more granted patents anticipated in the future. Lexaria’s DehydraTECH is suitable for a wide range of product formats – including pharmaceuticals, nutraceuticals, consumer packaged goods, and over-the-counter capsules, pills, tablets, and oral suspensions. The new incorporation of LEXX Nutra will allow the wholly-owned subsidiary to utilize DehydraTECH, or sublicense the use of DehydraTECH in various markets.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• Lexaria’s new patent includes claims for many types of nicotine, including nicotine benzoate, nicotine ditartrate, nicotine citrate, nicotine polacrilex, and many others, for use in sublingual delivery formats like oral pouches
• The global oral nicotine pouch market was valued at $4.69 billion in 2022 and is expected to grow to $11.91 billion by 2029, driven by the growing ban on e-cigarettes worldwide
• The white pouch category is one of the fastest-growing, tobacco-free alternatives to smoking and vaping – growing at a CAGR of 13.4%

Lexaria Bioscience (NASDAQ: LEXX), a global innovator of drug delivery platforms, has announced that the United States Patent and Trademark Office (“USPTO”) has granted a strategically important new patent in the oral nicotine sector for its patented DehydraTECH(TM) technology. The granting of the new patent further substantiates the superior DehydraTECH processing and sublingual compositions through exceptional scientific study results and recognition by the USPTO (https://cnw.fm/Sk9yh).

Lexaria’s new patent, US patent #11,700,875 Compositions and Methods For Sublingual Delivery of Nicotine, includes claims for many types of nicotine, including nicotine benzoate, nicotine ditartrate, nicotine citrate, nicotine polacrilex, and many others, for use in sublingual delivery formats like oral pouches. DehydraTECH-nicotine has shown in multiple sets of animal testing that it can be delivered to the bloodstream up to 10-times to 20-times faster at up to 10-fold higher levels of nicotine into blood plasma from oral absorption than concentration-matched controls. The speed of onset has proven vital to nicotine users.

The oral nicotine pouch category interests Lexaria and the nicotine products industry, growing partly because of its reduced risk of health outcomes, as the US Food and Drug Administration has previously noted. The white pouch delivery method specifically avoids harmful lung outcomes experienced by smokers or vapers. It involves absorption primarily through the buccal and sublingual tissues of the mouth of purified nicotine that has been separated from the harmful substances found in most other formats.

The global oral nicotine pouch market was valued at $4.69 billion in 2022 and is growing at a CAGR of 13.4% (https://cnw.fm/Hv5tb). By 2029, the market is expected to reach $11.91 billion – driven by multiple countries banning the sale of e-cigarettes, the devices used in vaping. Currently, 37 countries have banned these devices, representing a cumulative population of over 2.3 billion people (https://cnw.fm/SWyLu). The initial purpose of vaping was to help wean people off cigarette use, but it has become controversial and is limited in certain countries, with many restrictions and bans worldwide.

The US-granted patent is also progressing as a patent application through other jurisdictions internationally. The US patent and international patent applications are partly supported by the superior pharmacokinetic blood plasma data from Lexaria in its animal studies conducted from 2017 through 2021. This new patent builds nicely upon the company’s growing patent portfolio in the oral nicotine delivery sector, including the white pouch category for sublingual and buccal tissue delivery. The patents are built on a foundation of nicotine-specific patent filings dating back to 2019 and DehydraTECH patents dating back to 2016.

Lexaria’s DehydraTECH-nicotine has patents granted for oral nicotine delivery in the US, Canada, Australia, and is pending in numerous other countries. The white pouch category is one of the fastest growing, tobacco-free alternatives to smoking and vaping – emitting no smoke, odors, or vapors that can affect nearby persons and are a superior nicotine delivery method. Lexaria demonstrates this through its granted patents, subsequent studies, and future endeavors for sublingual and buccal delivery with DehydraTECH.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• Lexaria’s patented DehydraTECH(TM) technology enhances the performance of several categories of fat-soluble active molecules and drugs across oral and/or topical product formats
• This unique approach to drug delivery has earned Lexaria a total of 35 patents, with many patents pending worldwide
• The company continues active discussions with multi-billion dollar companies for the potential use of DehydraTECH in their commercial pursuits
• Lexaria is also actively seeking commercial partners during 2023 and 2024

Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, is out on an ambitious move to address conditions with high unmet needs. This focus has allowed them to make strides in the potential treatment of conditions such as hypertension, epilepsy, human hormone delivery, and nicotine replacement; all made possible through its patented technology, DehydraTECH(TM).

DehydraTECH enhances the performance of several categories of fat-soluble active molecules and drugs across oral and/or topical product formats. The technology serves as an additional step that can be easily incorporated into any formulation and manufacturing process, allowing for speedy delivery, an increase in bioavailability, and an increase in brain absorption, among other advantages (https://cnw.fm/LyMIC).

Lexaria’s studies have demonstrated a propensity for DehydraTECH technology to elevate the quantity of drug delivered across the blood-brain barrier by as much as 1,700 percent, which has opened the technology up to new possibilities for improved drug delivery.

One stand-out feature of DehydraTECH is its ability to work symbiotically with existing physiological systems to enable masking oral and olfactory receptors, rendering DehydraTECH-processed compounds mostly flavorless and odorless. This results in formulations not requiring sweeteners or chemical masking agents for flavor and odor blocking, meaning that manufacturers can create low-sugar products with fewer calories while avoiding excessive artificial sweeteners.

Once ingested, the compounds, through the help of fatty acids, permeate the intestinal wall for the active payload, then are transported to the systemic circulation by one of two pathways, typically dependent on the type of fatty acid(s) chosen for a given formulation. For hepatic transport, or where liver metabolism is desirable for biotransformation of the payload, Lexaria’s methodology uses medium-chain fatty acids. For lymphatic transport, on the other hand, Lexaria uses long-chain fatty acids, which are absorbed via the lymphatic lacteals, ultimately diverting them away from the liver and entering the general circulation very quickly.

DehydraTECH and its unique approach to drug delivery have earned Lexaria a current total of 35 patents across the United States, Canada, Mexico, Australia, Japan, India, and the European Union. Although it has already achieved considerable intellectual property protection through its existing patent portfolio, the company has a number of additional patents pending worldwide. These achievements have sparked interest across various industries. Lexaria’s CEO, Chris Bunka, has noted the company’s active discussions with multi-billion dollar companies for the potential use of its technology in their commercial product pursuits.

“Our applied R&D is paying off in spades because we are currently in active discussions with several multi-billion dollar companies around the world for the potential use of Lexaria’s DehydraTECH technology in their commercial product pursuits,” noted Mr. Bunka.

“These discussions are ongoing and have thus helped us to meet one of our primary objectives of the last year, which is to introduce DehydraTECH to world-leading potential collaborators,” he added (https://cnw.fm/yQagb).

Lexaria is ambitious in its push for DehydraTECH and is currently seeking commercial partners to use the technology in what are usually multi-billion-dollar markets. The company is taking steps to have multiple choices in how to fund its operations, and so far, it is on track to have 2023 as its best year ever.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

About CannabisNewsWire

CannabisNewsWire (CNW) is an information service that provides (1) access to our news aggregation and syndication servers, (2) CannabisNewsBreaks that summarize corporate news and information, (3) enhanced press release services, (4) social media distribution and optimization services, and (5) a full array of corporate communication solutions. As a multifaceted financial news and content distribution company with an extensive team of contributing journalists and writers, CNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. CNW has an ever-growing distribution network of more than 5,000 key syndication outlets across the country. By cutting through the overload of information in today’s market, CNW brings its clients unparalleled visibility, recognition and brand awareness. CNW is where news, content and information converge.

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• The article covers the concentration of cannabidiol in hypertensive women and men using the company’s patented DehydraTECH(TM)-processed CBD
• The global cardiovascular drugs market is expected to grow from $146.51 billion in 2021, reaching $173.48 billion in 2026, growing at a CAGR of 3.1%
• The article supports Lexaria’s efforts as it pursues IND status from the FDA for DehydraTECH-CBD as a potential treatment for hypertension
• Company is planning to begin preparations for a clinical trial that could start as early as the fourth quarter

Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, recently announced that its groundbreaking research utilizing its patented DehydraTECH(TM)-processed cannabidiol (DehydraTECH-CBD) has been published in eight peer-reviewed articles across six different publications. Lexaria’s research into DehydraTECH-CBD is being considered for indications including hypertension, diabetes, epilepsy, and more. Hypertension, heart disease, and diabetes are broad fields of interest for the company, with DehydraTECH-CBD generating positive pilot-study data.

“We’re proud of the impressive amount of research that our Company has been able to develop through its HYPER-H21 series of clinical studies that has now been assessed by a variety of our respected peers,” said John Docherty, President of Lexaria (https://cnw.fm/U97ZK). “Lexaria is establishing itself as one of the world’s leaders in the investigation of cannabidiol for the purposes of controlling human blood pressure, and we are now focused on launching an FDA-registered IND program to formally investigate DehydraTECH-CBD for hypertension this year.”

The global cardiovascular drugs market is expected to grow from $146.51 billion in 2021, reaching $173.48 billion in 2026, growing at a CAGR of 3.1%. The market’s growth is supported by the increase in sedentary jobs, busy lifestyles, and changing consumer preferences – factors affecting the disease profile in world populations. North America contributed as the largest cardiovascular drug region in 2021 (https://cnw.fm/xu8bk).

The most recent publication in June 2023 in the peer-reviewed International Journal of Molecular Sciences is “Differences in Plasma Cannabidiol Concentrations in Women and Men: A Randomized, Placebo-Controlled, Crossover Study” (https://cnw.fm/mmsva). The addition of this research article builds on the growing body of peer-reviewed literature developed by Lexaria’s leading research team into the effects of DehydraTECH-CBD and human health.

The findings and conclusions from the most recently published article revolve around the concentrations of CBD in a subject’s plasma and the bioavailability of the drug, examining the potential therapeutic benefits of CBD in the triple-blind study. Of the 62 hypertensive volunteers, concentrations of CBD were found to be higher in women and correlated with the proportion of adipose tissue. Lexaria found that the difference between the sexes was attributed to higher levels of fat tissue in women compared to men, and the men’s higher metabolism contributed to lower levels of CBD during the study.

Lexaria’s patented DehydraTECH technology improves how active pharmaceutical ingredients (“APIs”) enter the bloodstream by promoting healthier oral ingestion methods and increasing the effectiveness of fat-soluble molecules. DehydraTECH is covered by 34 granted patents and many pending patents.

The benefits of using DehydraTECH technology include:

• Improves the speed of onset, with effects felt in minutes
• Increased bioavailability by more effectively delivering the drug into the bloodstream
• Increased brain absorption, with testing suggesting up to 17x improvement
• Reduction in drug administration costs through a higher ratio of drug delivery

Lexaria’s next steps for its hypertension program include IND submission and additional preparations for its clinical trial. If the FDA clears the IND, Lexaria could begin its Phase Ib study as early as the fourth quarter of this year.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX

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